In verse 12, Paul writes that he trusts that Yahweh is able to guard all that he entrusts to Him - his life, future, plans, family, friends, ministry, etc.
Paul says to Timothy (young church-planter):

"Guard the good deposit that was entrusted to you - guard it with the help of the Holy Spirit who lives in us."

Let's look at that:
Guard - an action word - requires us to be intentional about being on guard against the enemy
Deposit - implies that what we've got is only a taste and that there is much more to come...
Entrusted - you entrust things to those who are found to be trustworthy servants and workmen approved
Help of the Holy Spirit - it's a tag team effort - us and Holy Spirit

After this big spiel, Paul then points out that two other guys (Phygelus and Hermogenes) who were working alongside of him ditched him - right after telling Timothy to guard his deposit. This fate of Phygelus and Hermogenes appears to be the outcome of those who don't guard themselves or work in submitted cooperation with Holy Spirit.

What does that mean to you? Are you more of a Timothy - eager to soak up the wisdom God has for you and willing to be disciplined and do what it takes to be productive in the Kingdom? Or do you have the sour flavour of Phygelus and Hermogenes - lovers of themselves and this world, submitted not to the Holy Spirit of the Living God, but instead making their gods their stomachs? Perhaps you are most like Paul - feeling abandoned by those whom you were pouring your life and teaching into. If so, keep at your work, this faith and love rooted in Christ. Amen.